Biology Biotechnology KMU 2025
PMDC Verified Question 41 of 65
In somatic cell hybridization, which two cells are fused to produce monoclonal antibodies?
A
T-cells and nerve cells
B
B-lymphocytes and spleen cells
C
T-cells and liver cells
D
B-lymphocytes and macrophages
Tap any option to test your recall and reveal the step-by-step Propolis autopsy.

Propolis Cognitive Error Autopsy

Official Correct Choice:
Option B: B-lymphocytes and spleen cells
Concept:

Hybridoma technology for monoclonal antibody manufacturing.

Solution:

Monoclonal antibodies are produced by somatic cell fusion between antibody-secreting B-lymphocytes (harvested from the spleen of an immunized host) and cancerous myeloma cells to grant immortality to the resulting hybridoma cell line.

Why other options are incorrect:

  • T-cells and nerve cells: T-cells perform cell-mediated immunity and do not secrete soluble antibodies; nerve cells do not divide or produce antibodies.


  • T-cells and liver cells: Neither T-lymphocytes nor hepatocytes synthesize immunoglobulin antibody molecules.


  • B-lymphocytes and macrophages: Macrophages are antigen-presenting phagocytic cells and do not form antibody-secreting hybrid lines.

Quality & Fidelity Assurance: Every question on BeambePrep is rigorously curated against the official PMDC syllabus with zero filler, zero out-of-syllabus content, and zero typos. When an authentic past paper originally contained a historical mistake or ambiguity from the examining board (such as UHS or NUMS), BeambePrep faithfully reflects the original paper while detailing the nuance and scientific consensus in the autopsy above.

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