Biology Digestion/Nutrition NUMS 2023
PMDC Verified Question 20 of 48
Intrinsic factor is secreted by:
A
Pancreas
B
Liver
C
Stomach
D
Duodenum
Tap any option to test your recall and reveal the step-by-step Propolis autopsy.

Propolis Cognitive Error Autopsy

Official Correct Choice:
Option C: Stomach
Concept:

Vitamin B12 is a massive molecule that cannot be absorbed through simple diffusion; it requires a specific binding protein to survive the intestinal tract.

Formula:

N/A

Solution:

  • The parietal (oxyntic) cells located in the mucosa of the Stomach have a dual function.
  • Alongside secreting HCl, they synthesize and secrete a glycoprotein called Intrinsic factor.
  • Intrinsic factor binds to dietary Vitamin B12, protecting it and allowing it to be absorbed much later in the terminal ileum.


Why other options are incorrect:

The pancreas, liver, and duodenum do not produce intrinsic factor. (Lack of intrinsic factor from the stomach leads to pernicious anemia).

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