Biology Enzymes SZABMU 2024
PMDC Verified Question 7 of 79
The Lock and Key Model (1894) was modified by:
A
Emil Fischer
B
Koshland
C
Kuhne
D
Camillo Golgi
Tap any option to test your recall and reveal the step-by-step Propolis autopsy.

Propolis Cognitive Error Autopsy

Official Correct Choice:
Option B: Koshland
Concept:

Scientific models evolve as new evidence emerges. The extreme rigidity of the 1894 enzyme model could not explain broad specificities or allosteric regulation.

Solution:

  • Emil Fischer proposed the original Lock and Key model in 1894.
  • Decades later, in 1959, Daniel Koshland recognized that enzymes were dynamic proteins, not rigid locks.
  • He proposed a modification known as the 'Induced Fit Model', stating that the active site is flexible and molds itself around the substrate.


Why other options are incorrect:

Emil Fischer created the original, unmodified model. Kuhne coined the term 'enzyme'. Camillo Golgi discovered the Golgi apparatus in cells, entirely unrelated to enzyme kinetic models.

Quality & Fidelity Assurance: Every question on BeambePrep is rigorously curated against the official PMDC syllabus with zero filler, zero out-of-syllabus content, and zero typos. When an authentic past paper originally contained a historical mistake or ambiguity from the examining board (such as UHS or NUMS), BeambePrep faithfully reflects the original paper while detailing the nuance and scientific consensus in the autopsy above.

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