Biology Immunity PMDC Conceptual Practice
PMDC Verified Question 46 of 99
In the Y-shaped structural architecture of an antibody molecule, the variable antigen-binding domains are located at the:

Question graphic
A
Upper tips of the Fab arms
B
Lower base of the Fc stem
C
Middle hinge region
D
Transmembrane anchor tail
Tap any option to test your recall and reveal the step-by-step Propolis autopsy.

Propolis Cognitive Error Autopsy

Official Correct Choice:
Option A: Upper tips of the Fab arms
Concept: Anatomy of the Y-shaped immunoglobulin molecule.

Solution: The variable domains of both heavy and light chains form the upper tips of the Fab (fragment antigen-binding) arms on the Y-shaped antibody structure.

Why other options are incorrect:
  • Option B: The lower base of the stem consists of constant heavy chain domains (Fc fragment).

  • Option C: The middle hinge allows flexibility between Fab arms and Fc stem.

  • Option D: The transmembrane tail anchors membrane-bound BCRs, not the variable binding sites.

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