PMDC Verified Question 32 of 47
Regular coiling and twisting of polypeptide chain caused by H-bonding in between NH and CO occurs ____
A
Tertiary structure
B
Primary structure
C
Secondary structure
D
Quaternary structure
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Propolis Cognitive Error Autopsy

Official Correct Choice:
Option C: Secondary structure
Concept:

Protein structure is organized hierarchically into primary, secondary, tertiary, and quaternary levels.

Formula:

$$N/A$$

Solution:

  • The primary structure is the linear sequence of amino acids (covalent peptide bonds).
  • When this linear chain begins to fold, it forms regular local patterns such as \( \alpha \)-helices (coiling) and \( \beta \)-pleated sheets (twisting/folding).
  • This localized folding is entirely stabilized by regular hydrogen bonds between the \( \text{N-H} \) and \( \text{C=O} \) groups of the peptide backbone. This level is defined as the secondary structure.


Why other options are incorrect:

Primary structure involves no H-bonding. Tertiary structure is the overall 3D folding stabilized by R-group interactions (disulfide, ionic, hydrophobic). Quaternary structure involves multiple polypeptide chains assembling together.

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