Chemistry Macromolecules / Biochemistry BUMHS 2022
PMDC Verified Question 28 of 47
Which enzyme is used for the treatment of blood cancer in children?
A
Thrombin
B
LDH-1
C
L-asparaginase
D
Zymase
Tap any option to test your recall and reveal the step-by-step Propolis autopsy.

Propolis Cognitive Error Autopsy

Official Correct Choice:
Option C: L-asparaginase
Concept:

Enzyme therapy leverages the metabolic weaknesses of specific cancer cells.

Formula:

$$N/A$$

Solution:

  • Childhood acute lymphoblastic leukemia (blood cancer) cells require circulating L-asparagine for survival because they lack the enzyme to synthesize it themselves.
  • By injecting L-asparaginase into the patient, the circulating L-asparagine is hydrolyzed into aspartic acid and ammonia.
  • Starved of this essential amino acid, the cancer cells undergo apoptosis (programmed cell death).


Why other options are incorrect:

Thrombin is used locally to stop bleeding. LDH-1 levels are diagnostic markers for heart attacks. Zymase is a yeast enzyme used in ethanol fermentation.

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