Biology Biotechnology PMDC Conceptual Practice
PMDC Verified Question 32 of 65
Familial hypercholesterolemia is treated ex-vivo by delivering receptor genes into:
A
Liver cells
B
Bone marrow cells
C
Kidney cells
D
Lung cells
Tap any option to test your recall and reveal the step-by-step Propolis autopsy.

Propolis Cognitive Error Autopsy

Official Correct Choice:
Option A: Liver cells
Concept:

Ex-vivo somatic gene therapy for metabolic receptor disorders.

Solution:

Familial hypercholesterolemia is caused by a lack of functional Low-Density Lipoprotein (LDL) receptors. Ex-vivo gene therapy involves surgical resection of patient liver cells (hepatocytes), retroviral insertion of normal LDL receptor genes, and re-infusion into the patient.

Why other options are incorrect:

  • Bone marrow cells: Targeted in gene therapy for immune disorders like SCID, not hypercholesterolemia.


  • Kidney cells: Filter metabolic wastes from blood, but do not clear circulating plasma LDL particles via LDL receptors.


  • Lung cells: Target tissue for in-vivo gene therapy of Cystic Fibrosis.

Quality & Fidelity Assurance: Every question on BeambePrep is rigorously curated against the official PMDC syllabus with zero filler, zero out-of-syllabus content, and zero typos. When an authentic past paper originally contained a historical mistake or ambiguity from the examining board (such as UHS or NUMS), BeambePrep faithfully reflects the original paper while detailing the nuance and scientific consensus in the autopsy above.

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