Biology Biotechnology PMDC Conceptual Practice
PMDC Verified Question 33 of 65
Cystic fibrosis gene therapy utilizes liposomes coated with normal genes sprayed into:
A
Bloodstream
B
Nostrils
C
Stomach
D
Muscle tissue
Tap any option to test your recall and reveal the step-by-step Propolis autopsy.

Propolis Cognitive Error Autopsy

Official Correct Choice:
Option B: Nostrils
Concept:

In-vivo aerosolized delivery of CFTR genes.

Solution:

Cystic fibrosis causes thick mucus accumulation in the respiratory tract. Treatment uses gene-loaded liposome aerosol sprays administered directly through the nostrils or respiratory airways.

Why other options are incorrect:

  • Bloodstream: Systemic vascular delivery does not concentrate liposomes effectively on respiratory epithelial surfaces.


  • Stomach: Gastric acids and digestive enzymes degrade lipid-DNA complexes.


  • Muscle tissue: Intramuscular delivery targets localized protein expression, not respiratory mucosal epithelia.

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