Biology Cell ETEA 2023
PMDC Verified Question 56 of 143
Tay-Sach's disease particularly results from the malfunctioning of:
A
Nucleus
B
Cell membrane
C
Vacuole
D
Lysosomes
Tap any option to test your recall and reveal the step-by-step Propolis autopsy.

Propolis Cognitive Error Autopsy

Official Correct Choice:
Option D: Lysosomes
Concept: Genetic defects in organelle enzymes lead to toxic buildup of substrates within the cell.

Solution: Tay-Sachs disease is a classic lysosomal storage disorder. It results from a genetic mutation that causes a severe deficiency in hexosaminidase A, a specific lipid-digesting enzyme located inside lysosomes. This causes toxic levels of lipids (gangliosides) to accumulate in brain cells.

Distractor Autopsy: Malfunctioning of the nucleus (DNA), cell membrane, or vacuole does not directly cause the specific enzymatic lipid buildup characteristic of Tay-Sachs.

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