Chemistry Macromolecules / Biochemistry MDCAT 2018
PMDC Verified Question 40 of 47
The stability in the following structure is due to the

Bond (1)
A
Hydrogen bonding between NH group of one peptide with another peptide
B
Disulfide bridges
C
Weak vander Waal's forces
D
Presence of unpaired electron in the structure
Tap any option to test your recall and reveal the step-by-step Propolis autopsy.

Propolis Cognitive Error Autopsy

Official Correct Choice:
Option A: Hydrogen bonding between NH group of one peptide with another peptide
Concept:

The secondary structure of proteins (like the \( \alpha \)-helix or \( \beta \)-pleated sheet) is stabilized by specific non-covalent interactions along the polypeptide backbone.

Formula:

$$ \text{>C=O} \cdots \text{H-N<} $$

Solution:

  • The given structure (\( \alpha \)-helix) maintains its coiled shape because of regular hydrogen bonds.
  • These hydrogen bonds form between the carbonyl oxygen (\( \text{C=O} \)) of one amino acid residue and the amide hydrogen (\( \text{N-H} \)) of another residue four positions down the chain.


Why other options are incorrect:

Disulfide bridges are covalent bonds that stabilize tertiary structure. Van der Waals forces contribute to tertiary packing, but H-bonds specifically define secondary structure. Unpaired electrons are irrelevant here.

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